Hi,

No, in Odoo 15, it is not possible to assign multiple routes on a Point of Sale (POS) item line. Each item line in the POS order can only have one route assigned to it.

In Odoo POS, the route is assigned to the product or product category, and it is inherited by the POS order lines. When a product is added to the POS order, the assigned route is automatically applied to the order line. However, if you need to apply multiple routes to a POS order line, you can use custom development to achieve this functionality.

Regards