Yes of course. When you're creating your invoice, you can do several partial invoices by choose the corresponding need in the field "What do you want to invoice?". Details of options :

• Invoice the whole sale.order
• Percentage : for invoice 10%, 20%, 30%, 50% etc as you want
• Fixed price(deposit) :  for deposit
• Some order lines : for invoice just particular lines of sale order.

You see you can create multiple invoices on one purchase Order because the process is the same both for sale order and purchase order.