It is a different exercise from simply putting 2 taxes on the product? That is, assuming you already have those taxes configured?
So Sales --> Product --> Product, under the Accounting tab.
While I don't know much about the USA, I can assume that state taxes differ per state. If that is the case, you might want to look into the fiscal positions option (we use that over here in Europe to provide shipments of goods to other neighbouring EU countries). You can then make a record for each state where taxes are being substituted per state. Don't forget to propertly configure your partners.